1,4-Dioxane hydrochloride → 1-{4-(3-Chloro-4-fluoro-phenyl)-6-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-pyrimidin-2-yl}-4-propyl-piperazin-2-one

Participants

Role	Name	HCID	Charge
Reactant	1,4-Dioxane hydrochloride	HCID 20443148	—
Reactant	4-{4-(3-Chloro-4-fluoro-phenyl)-6-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-pyrimidin-2-yl}-3-oxo-piperazine-1-carboxylic acid tert-butyl ester	HCID 57761145	—
Product	1-{4-(3-Chloro-4-fluoro-phenyl)-6-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-pyrimidin-2-yl}-4-propyl-piperazin-2-one	HCID 57761639	—

Reaction Steps

Treat 4-{4-(3-chloro-4-fluoro-phenyl)-6-[4-(3-trifluoromethyl-pyridin-2-yl)-piperazin-1-yl]-pyrimidin-2-yl}-3-oxo-piperazine-1-carboxylic acid tert-butyl ester with HCl/dioxane (4M) using the procedure described in Example 1-J step 3 to afford the title piperazine-one.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07566712B2
Source dataset	uspto-grants-2009_07
ORD ID	ord-da930d1dbcc14bc188adecc37081ac6c
Source note	uspto-grants-2009_07