Water → HCID 178481592, compound

HRID 2309516Notes

Reaction equation

HRID 2309516 reaction equation
[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]([NH:8][CH3:9])[C:3]=1[NH2:10].N[C:12](N)=O.[OH2:15]>>[Cl:1][C:2]1[N:7]=[CH:6][N:5]=[C:4]2[C:3]=1[N:10]=[C:9]([OH:15])[N:8]2[CH3:12]

Participants

4

Reactant 3

HCID 962WaterHCID 1176UreaHCID 3084776-chloro-N4-methylpyrimidine-4,5-diamine

Product 1

HCID 178481592HCID 178481592, compoundYield 60%

Conditions

Temperature
180 °C

Procedure

A mixture of 4.76 parts of 6-chloro-N4 methyl-4,5-pyrimidinediamine and 7.2 parts of urea was stirred and heated for 1 hour at 180° C. After cooling, the residue was suspended in water. The product was filtered off and dried, yielding 3.3 parts (60%) of 6-chloro-9-methyl-9H-purin-8-ol (intermediate 174).

Workup

  1. temperatureAfter cooling
  2. filtrationThe product was filtered off
  3. customdried

Sources & evidence

ORD record
ord-3646878c2bf84d539b08412887960c83
Source dataset
uspto-grants-1987_09
Patent number
US04695569

Reaction notes

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