反应详情

A mixture of 8 parts of ethyl 1-(phenylmethyl)-4-piperidineacetate hydrochloride and 80 parts of a dilute hydrochloric acid solution was stirred and refluxed for 4 hours. After cooling, the reaction mixture was evaporated. The residue was washed with 2-propanone and the solvent was evaporated again. The solid residue was washed with 2-propanone, filtered off and dried, yielding 6 parts of 1-(phenylmethyl)-4-piperidineacetic acid hydrochloride; mp. 137°-145° C. (2)

1. temperaturerefluxed for 4 hours
2. temperatureAfter cooling
3. customthe reaction mixture was evaporated
4. washThe residue was washed with 2-propanone
5. customthe solvent was evaporated again
6. washThe solid residue was washed with 2-propanone
7. filtrationfiltered off
8. customdried