Potassium Iodide → HCID 2800353, compound

HRID 2309610Notes

Reaction equation

HRID 2309610 reaction equation
Cl[C:2]1[C:7]([N+:8]([O-:10])=[O:9])=[CH:6][CH:5]=[CH:4][N:3]=1.[S:11]1[CH:15]=[CH:14][CH:13]=[C:12]1[CH2:16][NH2:17].C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+]>O.CN(C)C(=O)C>[N+:8]([C:7]1[C:2]([NH:17][CH2:16][C:12]2[S:11][CH:15]=[CH:14][CH:13]=2)=[N:3][CH:4]=[CH:5][CH:6]=1)([O-:10])=[O:9]

Participants

7

Reactant 4

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 34005(2-Thienylmethyl)amineHCID 796132-Chloro-3-nitropyridine

Product 1

HCID 2800353HCID 2800353, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 31374DimethylacetamideSolvent

Conditions

Temperature
100 °C

Procedure

A mixture of 180.0 parts of 2-chloro-3-nitropyridine, 122.0 parts of 2-thiophenemethanamine, 191.0 parts of sodium carbonate, 1 part of potassium iodide and 810 parts of N,N-dimethylacetamide was stirred for 1.50 hours at 100° C. The reaction mixture was poured into about 4000 parts of water. The whole was stirred overnight at room temperature. The precipitated product was filtered off and dried in vacuo at 40° C., yielding 251.5 parts of 3-nitro-N-(2-thienylmethyl)-2-pyridinamine; mp. 100° C. (8).

Workup

  1. stirringThe whole was stirred overnight at room temperature
  2. filtrationThe precipitated product was filtered off
  3. customdried in vacuo at 40° C.

Sources & evidence

ORD record
ord-7832d14885eb4b0d81edd5895d955eea
Source dataset
uspto-grants-1987_09
Patent number
US04695575

Reaction notes

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