HCID 14518041, compound → HCID 14518061, compound

HRID 2309644Notes

Reaction equation

HRID 2309644 reaction equation
[IH:1].[CH3:2][O:3][CH:4]([O:12][CH3:13])[CH2:5][NH:6][C:7](SC)=[N:8][CH3:9].[F:14][C:15]1[CH:20]=[CH:19][C:18]([CH2:21][N:22]2[C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=3[N:24]=[C:23]2[CH2:31][CH:32]2[CH2:37][CH2:36][N:35]([CH2:38][CH2:39][NH2:40])[CH2:34][CH2:33]2)=[CH:17][CH:16]=1>CC(O)C>[IH:1].[CH3:2][O:3][CH:4]([O:12][CH3:13])[CH2:5][NH:6][C:7]([NH:40][CH2:39][CH2:38][N:35]1[CH2:36][CH2:37][CH:32]([CH2:31][C:23]2[N:22]([CH2:21][C:18]3[CH:17]=[CH:16][C:15]([F:14])=[CH:20][CH:19]=3)[C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=3[N:24]=2)[CH2:33][CH2:34]1)=[N:8][CH3:9]

Participants

4

Reactant 2

HCID 14518041HCID 14518041, compoundHCID 19377717HCID 19377717, compound

Product 1

HCID 14518061HCID 14518061, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

A mixture of 6.4 parts of methyl N-(2,2-dimethoxyethyl)-N'-methylcarbamimidothioate monohydroiodide, 7.3 parts of 4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]methyl]-1-piperidineethanamine and 80 parts of 2-propanol was stirred and refluxed overnight. The reaction mixture was evaporated, yielding 12.77 parts (99%) of N-(2,2-dimethoxyethyl)-N'-[2-[4-[[1-[(4-fluorophenyl)methyl]-1H-benzimidazol-2-yl]methyl]-1-piperidinyl]ethyl]N"-methylguanidine monohydroiodide (450).

Workup

  1. temperaturerefluxed overnight
  2. customThe reaction mixture was evaporated

Sources & evidence

ORD record
ord-39d3ca49ac914e4986069e2aa63e7060
Source dataset
uspto-grants-1987_09
Patent number
US04695575

Reaction notes

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