Methylamine → HCID 178485300, compound

Participants

Reaction Steps

Methyl 3-(2-guanidinothiazol-4-yl)cyclopentane carboxylate (0.40 g.) and a solution of methylamine in EtOH (33% w/v; 15 ml.) was allowed to stand at ambient temperature for 60 hours. The solvent was removed by evaporation in vacuo and the residue was purified by medium pressure chromatography on silica gel using CHCl3 /MeOH/aqueous ammonia (s.g. 0.88) 8:2:0.3 v/v/v as eluant to give N-methyl-3-(2-guanidinothiazol-4-yl)cyclopentane carboxamide (0.27 g.), m.p. 216°-218°.

Provenance & Evidence