Methylamine → HCID 178485300, compound

HRID 2309719Notes

Reaction equation

HRID 2309719 reaction equation
[NH:1]([C:5]1[S:6][CH:7]=[C:8]([CH:10]2[CH2:14][CH2:13][CH:12]([C:15]([O:17]C)=O)[CH2:11]2)[N:9]=1)[C:2]([NH2:4])=[NH:3].[CH3:19][NH2:20]>CCO>[CH3:19][NH:20][C:15]([CH:12]1[CH2:13][CH2:14][CH:10]([C:8]2[N:9]=[C:5]([NH:1][C:2]([NH2:4])=[NH:3])[S:6][CH:7]=2)[CH2:11]1)=[O:17]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 178497561HCID 178497561, compound

Product 1

HCID 178485300HCID 178485300, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Methyl 3-(2-guanidinothiazol-4-yl)cyclopentane carboxylate (0.40 g.) and a solution of methylamine in EtOH (33% w/v; 15 ml.) was allowed to stand at ambient temperature for 60 hours. The solvent was removed by evaporation in vacuo and the residue was purified by medium pressure chromatography on silica gel using CHCl3 /MeOH/aqueous ammonia (s.g. 0.88) 8:2:0.3 v/v/v as eluant to give N-methyl-3-(2-guanidinothiazol-4-yl)cyclopentane carboxamide (0.27 g.), m.p. 216°-218°.

Workup

  1. customThe solvent was removed by evaporation in vacuo
  2. customthe residue was purified by medium pressure chromatography on silica gel

Sources & evidence

ORD record
ord-ad288640e5cb4880bdd614f7769144d2
Source dataset
uspto-grants-1987_09
Patent number
US04696933

Reaction notes

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