1-Bromo-3-chloropropane → HCID 20067710, compound

HRID 2309774Notes

Reaction equation

HRID 2309774 reaction equation
[C:1]1([C:7]([CH2:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=2)=[O:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH2:17][CH2:18][CH2:19][Cl:20]>>[Cl:20][CH2:19][CH2:18][CH2:17][CH:9]([C:10]1[CH:11]=[CH:12][CH:13]=[CH:14][CH:15]=1)[C:7]([C:1]1[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1)=[O:8]

Participants

3

Reactant 2

HCID 80061-Bromo-3-chloropropaneHCID 99482-Phenylacetophenone

Product 1

HCID 20067710HCID 20067710, compound

Procedure

The compound is prepared from 19.6 g of desoxybenzoin, which is alkylated with 15.8 g of 3-bromo-1-chloropropane according to the procedure described in Example 17, method 1, except that the reaction time is only 15 min at room temperature. The product is recrystallized from methanol. The yield is 16.6 g (61%) of a product having m.p. 72°-4° C.

Workup

  1. customThe product is recrystallized from methanol

Sources & evidence

ORD record
ord-864cd803b40f4681a4c0fb8ce554217f
Source dataset
uspto-grants-1987_09
Patent number
US04696949

Reaction notes

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