Methylamine → 3-Methoxy-N-methyl-4-(7H-purin-8-yl)benzamide

HRID 2309881Notes

Reaction equation

HRID 2309881 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([NH2:11])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:14](=[N:15][CH:16]=[N:17][CH:18]=2)[N:13]=1.[CH3:21]N>>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([C:9]([NH:11][CH3:21])=[O:10])[CH:6]=[CH:5][C:4]=1[C:12]1[NH:20][C:19]2[C:14](=[N:15][CH:16]=[N:17][CH:18]=2)[N:13]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 132845313-Methoxy-4-(7H-purin-8-yl)benzamide

Product 1

HCID 132845323-Methoxy-N-methyl-4-(7H-purin-8-yl)benzamide

Procedure

Forty milliliters of ethanolic methylamine solution were added to 0.42 gm of 8-(2'-methoxy-4'-chlorocarbonyl-phenyl)-purine hydrochloride (see Example 43), with cooling, and the mixture was refluxed for 30 minutes. It was then concentrated by evaporation, and the product was purified by column chromatography on silica gel [eluant:methylene chloride/ethanol (8:2)].

Workup

  1. temperaturewith cooling
  2. temperaturethe mixture was refluxed for 30 minutes
  3. concentrationIt was then concentrated by evaporation
  4. customthe product was purified by column chromatography on silica gel [eluant:methylene chloride/ethanol (8:2)]

Sources & evidence

ORD record
ord-b3ed7aabd58745a6bdb04927d2863c8a
Source dataset
uspto-grants-1987_09
Patent number
US04696931

Reaction notes

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