Morpholine → 8-[2-Methoxy-4-(morpholine-4-sulfonyl)phenyl]-7H-purine

HRID 2309888Notes

Reaction equation

HRID 2309888 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl.[CH3:8][O:9][C:10]1[CH:15]=[C:14]([S:16](Cl)(=[O:18])=[O:17])[CH:13]=[CH:12][C:11]=1[C:20]1[NH:28][C:27]2[C:22](=[N:23][CH:24]=[N:25][CH:26]=2)[N:21]=1>C(OCC)(=O)C.O>[CH3:8][O:9][C:10]1[CH:15]=[C:14]([S:16]([N:1]2[CH2:6][CH2:5][O:4][CH2:3][CH2:2]2)(=[O:18])=[O:17])[CH:13]=[CH:12][C:11]=1[C:20]1[NH:28][C:27]2[C:22](=[N:23][CH:24]=[N:25][CH:26]=2)[N:21]=1

Participants

5

Reactant 2

HCID 8083MorpholineHCID 20184500HCID 20184500, compound

Product 1

HCID 132845378-[2-Methoxy-4-(morpholine-4-sulfonyl)phenyl]-7H-purine

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8857Ethyl AcetateSolvent

Conditions

Temperature
80 °C

Procedure

An amount of 0.8 ml of morpholine was dissolved in a two-phase mixture of 40 ml of ethyl acetate and 40 ml of water. Then, 1 gm of crude 8-(2'-methoxy-4'-chlorosulfonylphenyl)-purine hydrochloride was added thereto in batches, under vigorous stirring, and the resulting mixture was heated to 80° C. for two hours. The reaction mixture was concentrated down to one-third of the volume, and the crystals precipitated were subjected to suction filtration and washed with water.

Workup

  1. concentrationThe reaction mixture was concentrated down to one-third of the volume
  2. customthe crystals precipitated
  3. filtrationwere subjected to suction filtration
  4. washwashed with water

Sources & evidence

ORD record
ord-5c1dd2b633534cef8293b4ae8b2c3385
Source dataset
uspto-grants-1987_09
Patent number
US04696931

Reaction notes

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