Butylamine → N-Butyl-3-methoxy-4-(7H-purin-8-yl)benzene-1-sulfonamide

HRID 2309889Notes

Reaction equation

HRID 2309889 reaction equation
[CH2:1]([NH2:5])[CH2:2][CH2:3][CH3:4].Cl.[CH3:7][O:8][C:9]1[CH:14]=[C:13]([S:15](Cl)(=[O:17])=[O:16])[CH:12]=[CH:11][C:10]=1[C:19]1[NH:27][C:26]2[C:21](=[N:22][CH:23]=[N:24][CH:25]=2)[N:20]=1>>[CH3:7][O:8][C:9]1[CH:14]=[C:13]([S:15]([NH:5][CH2:1][CH2:2][CH2:3][CH3:4])(=[O:17])=[O:16])[CH:12]=[CH:11][C:10]=1[C:19]1[NH:27][C:26]2[C:21](=[N:22][CH:23]=[N:24][CH:25]=2)[N:20]=1

Participants

3

Reactant 2

HCID 8007ButylamineHCID 20184500HCID 20184500, compound

Product 1

HCID 13284538N-Butyl-3-methoxy-4-(7H-purin-8-yl)benzene-1-sulfonamide

Procedure

Prepared analogously to Example 51 from n-butylamine and 8-(2'-methoxy-4'-chlorosulfonyl-phenyl)-purine hydrochloride. After the reaction finished, the aqueous phase wsa extracted with ethyl acetate. The residue remaining after the ethyl acetate phases were evaporated was digested with ethanol, subjected to suction filtration, and washed with water.

Workup

  1. extractionthe aqueous phase wsa extracted with ethyl acetate
  2. customwere evaporated
  3. filtrationsubjected to suction filtration
  4. washwashed with water

Sources & evidence

ORD record
ord-be112d36ebf34269bb4d9373b5ffe902
Source dataset
uspto-grants-1987_09
Patent number
US04696931

Reaction notes

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