Methyl Isocyanate → HCID 20184542, compound

HRID 2309908Notes

Reaction equation

HRID 2309908 reaction equation
[NH2:1][C:2]1[CH:23]=[CH:22][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13][C:12]([O:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:11][C:10]=3[O:20][CH3:21])[NH:8][C:4]=2[CH:3]=1.[CH3:24][N:25]=[C:26]=[O:27]>O1CCCC1>[CH3:24][NH:25][C:26]([NH:1][C:2]1[CH:23]=[CH:22][C:5]2[N:6]=[C:7]([C:9]3[CH:14]=[CH:13][C:12]([O:15][S:16]([CH3:19])(=[O:18])=[O:17])=[CH:11][C:10]=3[O:20][CH3:21])[NH:8][C:4]=2[CH:3]=1)=[O:27]

Participants

4

Reactant 2

HCID 12228Methyl IsocyanateHCID 20184521HCID 20184521, compound

Product 1

HCID 20184542HCID 20184542, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

One gram (3.0 mmol) of 5-amino-2-(2'-methoxy-4'-methanesulfonyloxy-phenyl)-benzimidazole was dissolved in 30 ml of pure tetrahydrofuran, 2.0 ml of methylisocyanate were added, and the mixture was refluxed. After 15 minutes that solvent and any excess methylisocyanate were evaporated off in vacuo, and the residue obtained was chromatographed over 250 gm of aluminium oxide (neutral) (eluant: methylene chloride with 4% ethanol).

Workup

  1. temperaturethe mixture was refluxed
  2. customany excess methylisocyanate were evaporated off in vacuo
  3. customthe residue obtained
  4. customwas chromatographed over 250 gm of aluminium oxide (neutral) (eluant: methylene chloride with 4% ethanol)

Sources & evidence

ORD record
ord-e84a37f80ced475c85ed29204c29fd8a
Source dataset
uspto-grants-1987_09
Patent number
US04696931

Reaction notes

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