HRID230999

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID3672

Ibuprofen

C13H18O2

结构：COc1ccc2c3c1O[C@H]1[C@@H](O)C=C[C@H]4[C@@H](C2)N(C)CC[C@@]341

HCID5284371

Codeine

C18H21NO3

2 次

PRODUCTS

生成物

结构：CC(C)Cc1ccc(C(C)C(=O)O)cc1.COc1ccc2c3c1O[C@H]1[C@@H](O)C=C[C@H]4[C@@H](C2)N(C)CC[C@@]341

HCID9849057

未命名化合物

PROCEDURE

实验过程

Codeine Phosphate, microcrystalline cellulose and intragranular Starch 1500 were dry mixed. Water was then added and the mixture was granulated to form pharmaceutical, codeine containing granules. Starch 1500 was then mixed with the granules. Finally the codeine and ibuprofen granules were compressed to give an ibuprofen-codeine bi-layer tablet with a crushing strength of 11-12 kp.

WORKUP

后处理

dry with materialCodeine Phosphate, microcrystalline cellulose and intragranular Starch 1500 were dry
additionmixed
additionWater was then added
customto form pharmaceutical

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-267d20c8e06541fe9a03ac3aeb932b0a
来源数据集: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04844907
来源说明: uspto-grants-1989_07

反应 SMILES

[CH3:1][N:2]1[C@@H:18]2[CH2:19][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C@@H:14]([OH:20])[CH:15]=[CH:16][C@@H:17]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1.[OH:23][C:24]([CH:26]([C:28]1[CH:37]=[CH:36][C:31]([CH2:32][CH:33]([CH3:35])[CH3:34])=[CH:30][CH:29]=1)[CH3:27])=[O:25]>>[OH:25][C:24]([CH:26]([C:28]1[CH:29]=[CH:30][C:31]([CH2:32][CH:33]([CH3:34])[CH3:35])=[CH:36][CH:37]=1)[CH3:27])=[O:23].[CH3:1][N:2]1[C@@H:18]2[CH2:19][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C@@H:14]([OH:20])[CH:15]=[CH:16][C@@H:17]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1