Ibuprofen, (+-)- → Ibuprofen codeine

HRID 230999Notes

Reaction equation

HRID 230999 reaction equation
[CH3:1][N:2]1[C@@H:18]2[CH2:19][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C@@H:14]([OH:20])[CH:15]=[CH:16][C@@H:17]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1.[OH:23][C:24]([CH:26]([C:28]1[CH:37]=[CH:36][C:31]([CH2:32][CH:33]([CH3:35])[CH3:34])=[CH:30][CH:29]=1)[CH3:27])=[O:25]>>[OH:25][C:24]([CH:26]([C:28]1[CH:29]=[CH:30][C:31]([CH2:32][CH:33]([CH3:34])[CH3:35])=[CH:36][CH:37]=1)[CH3:27])=[O:23].[CH3:1][N:2]1[C@@H:18]2[CH2:19][C:7]3[CH:8]=[CH:9][C:10]([O:21][CH3:22])=[C:11]4[O:12][C@H:13]5[C@@H:14]([OH:20])[CH:15]=[CH:16][C@@H:17]2[C@:5]5([C:6]=34)[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 3672Ibuprofen, (+-)-HCID 5284371Codeine2×

Product 1

HCID 9849057Ibuprofen codeine

Procedure

Codeine Phosphate, microcrystalline cellulose and intragranular Starch 1500 were dry mixed. Water was then added and the mixture was granulated to form pharmaceutical, codeine containing granules. Starch 1500 was then mixed with the granules. Finally the codeine and ibuprofen granules were compressed to give an ibuprofen-codeine bi-layer tablet with a crushing strength of 11-12 kp.

Workup

  1. dry with materialCodeine Phosphate, microcrystalline cellulose and intragranular Starch 1500 were dry
  2. additionmixed
  3. additionWater was then added
  4. customto form pharmaceutical

Sources & evidence

ORD record
ord-267d20c8e06541fe9a03ac3aeb932b0a
Source dataset
uspto-grants-1989_07
Patent number
US04844907

Reaction notes

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