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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 230999Generated: October 25, 2026

Ibuprofen, (+-)- → Ibuprofen codeine

https://huagongshe.com/reaction/230999

Reaction equation

Participants

RoleNameHCIDCharge
ReactantIbuprofen, (+-)-HCID 3672—
ReactantCodeineHCID 5284371—
ProductIbuprofen codeineHCID 9849057—

Reaction Steps

Codeine Phosphate, microcrystalline cellulose and intragranular Starch 1500 were dry mixed. Water was then added and the mixture was granulated to form pharmaceutical, codeine containing granules. Starch 1500 was then mixed with the granules. Finally the codeine and ibuprofen granules were compressed to give an ibuprofen-codeine bi-layer tablet with a crushing strength of 11-12 kp.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04844907
Source datasetuspto-grants-1989_07
ORD IDord-267d20c8e06541fe9a03ac3aeb932b0a
Source noteuspto-grants-1989_07