Acetic Acid → 4-Phenyl-alpha,alpha,1-trimethyl-4-piperidinemethanol

HRID 2310048Notes

Reaction equation

HRID 2310048 reaction equation
[BH4-:22].[C:18]([BH3-:19])#[N:20].[CH3:26][OH:27].[CH3:28][C:29](=[O:30])[OH:31].[ClH:23].[Na+:21].[Na+:25].[OH-:24].[c:1]1([C:7]23[CH2:8][CH2:9][N:10]([CH3:17])[CH:11]([O:12][C:13]2([CH3:14])[CH3:15])[CH2:16]3)[cH:2][cH:3][cH:4][cH:5][cH:6]1>>[c:1]1([C:7]2([C:13]([OH:12])([CH3:14])[CH3:15])[CH2:8][CH2:9][N:10]([CH3:17])[CH2:11][CH2:16]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

9

Reactant 8

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 887MethanolHCID 923Sodium ion2×HCID 961HydroxideHCID 28123BorohydrideHCID 498716Cyano-borohydrideHCID 540271932,6,6-Trimethyl-5-phenyl-7-oxa-2-azabicyclo[3.2.1]octane

Product 1

HCID 133634034-Phenyl-alpha,alpha,1-trimethyl-4-piperidinemethanol

Sources & evidence

ORD record
ord-102c93f452864494b57b6baf57bdeecc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

Loading…