Tetrahydrofuran → 5-Bromo-3-(1-Methylpiperidin-4-yl)-1-Triisopropylsilylindole

HRID 2310105Notes

Reaction equation

HRID 2310105 reaction equation
[Br:2][c:3]1[cH:4][c:5]2[c:6]([CH:12]3[CH2:13][CH2:14][N:15]([CH3:18])[CH2:16][CH2:17]3)[cH:7][nH:8][c:9]2[cH:10][cH:11]1.[F:19][C:20]([F:21])([F:22])[S:23]([O:24][Si:25]([CH:26]([CH3:27])[CH3:28])([CH:29]([CH3:30])[CH3:31])[CH:32]([CH3:33])[CH3:34])(=[O:35])=[O:36].[KH:1].[O:37]1[CH2:38][CH2:39][CH2:40][CH2:41]1>>[Br:2][c:3]1[cH:4][c:5]2[c:6]([CH:12]3[CH2:13][CH2:14][N:15]([CH3:18])[CH2:16][CH2:17]3)[cH:7][n:8]([Si:25]([CH:26]([CH3:27])[CH3:28])([CH:29]([CH3:30])[CH3:31])[CH:32]([CH3:33])[CH3:34])[c:9]2[cH:10][cH:11]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 2724529Triisopropylsilyl trifluoromethanesulfonateHCID 157453445-bromo-3-(1-methylpiperidin-4-yl)-1H-indoleHCID 178506623HCID 178506623, compound

Product 1

HCID 120859685-Bromo-3-(1-Methylpiperidin-4-yl)-1-Triisopropylsilylindole

Sources & evidence

ORD record
ord-91a0203cf976482ba721e78580ddee47
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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