Aziridine, 1-acetyl- → HCID 20034384, compound

HRID 231036Notes

Reaction equation

HRID 231036 reaction equation
[NH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1.[C:11]([N:14]1[CH2:16][CH2:15]1)(=[O:13])[CH3:12]>CO>[C:11]([NH:14][CH2:15][CH2:16][N:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3][CH2:2]1)(=[O:13])[CH3:12]

Participants

4

Reactant 2

HCID 9994Aziridine, 1-acetyl-HCID 694601,2,3,4-Tetrahydroquinoline

Product 1

HCID 20034384HCID 20034384, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

13.3 g. (0.1 mol) 1,2,3,4-tetrahydroquinoline and 9.4 g. (0.11 mol) acetylaziridine were boiled overnight under reflux in 200 ml. anhydrous methanol. After evaporating in a rotary evaporator, the mixture obtained of unreacted starting material and reaction product (13 g.) was purified by column chromatography on silica gel (elution agent: chloroform/acetone=4/1 v/v; m.p. 102° C.

Workup

  1. temperatureunder reflux in 200 ml
  2. customAfter evaporating in a rotary evaporator
  3. customthe mixture obtained
  4. custommaterial and reaction product (13 g.)
  5. customwas purified by column chromatography on silica gel (
  6. washelution agent

Sources & evidence

ORD record
ord-d5f26bf7b08e43dca2fb5eb5c03e9516
Source dataset
uspto-grants-1989_07
Patent number
US04845030

Reaction notes

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