反应详情

2.7 g of 1-(3-trifluoromethylbenzyl)-3-methylmercapto-4-cyano-5-amino-pyrazole are dissolved in 30 ml of chloroform. A mixture of 1.8 g of 3-chloroperbenzoic acid and 20 ml of chloroform are added dropwise to this solution at 20° C. and stirred for 15 hours. The mixture is subsequently washed with saturated sodium bicarbonate solution, 2% strength sodium thiosulphate solution, and again with saturated aqueous sodium bicarbonate solution. The organic phase is dried using anhydrous sodium sulphate, concentrated, and triturated in petroleum ether. 2.2 g (75% of theory) of 1-(3-trifluoromethylbenzyl)-3-methylsulphinyl-4-cyano-5-amino-pyrazole of melting point 143° C. are obtained.

1. additionare added dropwise to this solution at 20° C.
2. washThe mixture is subsequently washed with saturated sodium bicarbonate solution, 2% strength sodium thiosulphate solution
3. customThe organic phase is dried
4. concentrationconcentrated
5. customtriturated in petroleum ether