Carbon Dioxide → HCID 14551033, compound

HRID 231078Notes

Reaction equation

HRID 231078 reaction equation
[Cl:1][CH2:2][C:3](Cl)=[O:4].C(=O)=O.[NH2:9][C:10]1[CH:11]=[CH:12][C:13]([O:16][CH3:17])=[N:14][CH:15]=1>CCOCC>[ClH:1].[CH3:17][O:16][C:13]1[CH:12]=[CH:11][C:10]([NH:9][C:3](=[O:4])[CH2:2][Cl:1])=[CH:15][N:14]=1

Participants

5

Reactant 3

HCID 280Carbon DioxideHCID 6577Chloroacetyl chlorideHCID 811216-Methoxy-3-pyridinylamine

Product 1

HCID 14551033HCID 14551033, compoundYield 90.3%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

Chloroacetyl chloride (8.0 ml, 0.10 mol) was added over a period of 10 minutes with cooling (dry ice bath) to a solution of 5-amino-2-methoxypyridine (11 ml, 0.10 mol) and ether (100 ml). After one hour the reaction wsa filtered and the solid collected and washed with ether to give 10.7 g of the title compound, m.p. 155°-160° C. The title product was identified by IR, NMR and MS analysis.

Workup

  1. filtrationAfter one hour the reaction wsa filtered
  2. customthe solid collected
  3. washwashed with ether

Sources & evidence

ORD record
ord-acb7ecc1e24240989123c6f9776c08e6
Source dataset
uspto-grants-1989_07
Patent number
US04845107

Reaction notes

Loading…