反应详情

5.0 g of 5-chloro-4-{2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethylamino}-6-methylpyrimidine (powder) were suspended in 10 ml of water, and 5 ml of concentrated aqueous hydrochloric acid were added dropwise thereto. After this addition, the mixture was stirred for 30 minutes, and cooled to separate the crystals. These crystals were collected by filtration and washed with cold water and toluene, in that order, to give 5.2 g of the title compound as colorless needles melting at 123°-124° C.

1. additionAfter this addition
2. temperaturecooled
3. customto separate the crystals
4. filtrationThese crystals were collected by filtration
5. washwashed with cold water and toluene, in that order