Hydrochloric Acid → 5-Chloro-4-{2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethylamino}-6-methylpyrimidine hydrochloride

HRID 231116Notes

Reaction equation

HRID 231116 reaction equation
[Cl:1][C:2]1[C:3]([NH:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][O:21][CH2:22][CH3:23])=[CH:15][C:14]=2[CH3:24])=[N:4][CH:5]=[N:6][C:7]=1[CH3:8].Cl>O>[ClH:1].[Cl:1][C:2]1[C:3]([NH:9][CH2:10][CH2:11][O:12][C:13]2[CH:18]=[CH:17][C:16]([CH2:19][CH2:20][O:21][CH2:22][CH3:23])=[CH:15][C:14]=2[CH3:24])=[N:4][CH:5]=[N:6][C:7]=1[CH3:8]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13909969HCID 13909969, compound

Product 1

HCID 200345095-Chloro-4-{2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethylamino}-6-methylpyrimidine hydrochlorideYield 188.4%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

5.0 g of 5-chloro-4-{2-[4-(2-ethoxyethyl)-2-methylphenoxy]ethylamino}-6-methylpyrimidine (powder) were suspended in 10 ml of water, and 5 ml of concentrated aqueous hydrochloric acid were added dropwise thereto. After this addition, the mixture was stirred for 30 minutes, and cooled to separate the crystals. These crystals were collected by filtration and washed with cold water and toluene, in that order, to give 5.2 g of the title compound as colorless needles melting at 123°-124° C.

Workup

  1. additionAfter this addition
  2. temperaturecooled
  3. customto separate the crystals
  4. filtrationThese crystals were collected by filtration
  5. washwashed with cold water and toluene, in that order

Sources & evidence

ORD record
ord-20437f4510864f1aae23711a4612b5f0
Source dataset
uspto-grants-1989_07
Patent number
US04845097

Reaction notes

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