Triethylamine → 2-(4-Methoxy-2-picolylmercapto)-1H-thieno[3,4-d]imidazole

HRID 231152Notes

Reaction equation

HRID 231152 reaction equation
Cl.Cl.[CH3:3][O:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]([CH2:11][S:12][C:13]2[NH:17][C:16]3=[CH:18][S:19][CH:20]=[C:15]3[N:14]=2)[CH:6]=1.C(N(CC)CC)C>CO>[CH3:3][O:4][C:5]1[CH:10]=[CH:9][N:8]=[C:7]([CH2:11][S:12][C:13]2[NH:14][C:15]3=[CH:20][S:19][CH:18]=[C:16]3[N:17]=2)[CH:6]=1

Participants

4

Reactant 2

HCID 8471TriethylamineHCID 139233702-(4-Methoxy-2-picolylmercapto)-1H-thieno[3,4-d]imidazole dihydrochloride

Product 1

HCID 139233692-(4-Methoxy-2-picolylmercapto)-1H-thieno[3,4-d]imidazole

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

2.1 g of 2-(4-methoxy-2-picolylmercapto)-1H-thieno[3,4-d]imidazole dihydrochloride were suspended in 100 ml of methanol, and 1.9 g of triethylamine were then added. The resulting solution was stirred at room temperature for about one hour, and the solvent was removed by distillation. After addition of 50 ml of water, the mixture was stirred at room temperature for about one hour, and the crystals were filtered off with suction, dried and recrystallized from ethanol in the presence of active charcoal. Colorless crystals, melting point 172°-175° C.

Workup

  1. customthe solvent was removed by distillation
  2. additionAfter addition of 50 ml of water
  3. stirringthe mixture was stirred at room temperature for about one hour
  4. filtrationthe crystals were filtered off with suction
  5. customdried
  6. customrecrystallized from ethanol in the presence of active charcoal

Sources & evidence

ORD record
ord-7cef038aaebb4c32a3aad0a5ce207c09
Source dataset
uspto-grants-1989_07
Patent number
US04845118

Reaction notes

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