Tetrahydrofuran → 5-(Trifluoromethyl)indan-1-one
Reaction equation
[Br:1][c:2]1[c:3]([CH2:12][CH2:13][C:14](=[O:15])[OH:16])[cH:4][c:5]([C:8]([F:9])([F:10])[F:11])[cH:6][cH:7]1.[CH2:17]([Li:18])[CH2:19][CH2:20][CH3:21].[CH2:22]1[O:23][CH2:24][CH2:25][CH2:26]1.[CH3:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32]>>[c:2]12[c:3]([cH:4][c:5]([C:8]([F:9])([F:10])[F:11])[cH:6][cH:7]1)[CH2:12][CH2:13][C:14]2=[O:16]Participants
5
Sources & evidence
- ORD record
- ord-ceb20e35631e4a409cdde63fe38c9f67
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
Loading…