Thionyl Chloride → HCID 14154317, compound

HRID 231156Notes

Reaction equation

HRID 231156 reaction equation
[Cl:1][C:2]1[C:3]([CH2:10]O)=[N:4][CH:5]=[CH:6][C:7]=1[O:8][CH3:9].S(Cl)([Cl:14])=O>ClCCl>[ClH:1].[Cl:1][C:2]1[C:3]([CH2:10][Cl:14])=[N:4][CH:5]=[CH:6][C:7]=1[O:8][CH3:9]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 14154315HCID 14154315, compound

Product 1

HCID 14154317HCID 14154317, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a mixture of 2.6 g of 3-chloro-2-hydroxymethyl-4-methoxypyridine and 30 ml of dichloromethane at -10 to -15° C. was added dropwise a solution of 3.5 ml of thionyl chloride in 25 ml of dichloromethane, and then the mixture was stirred at room temperature for 2 hours. The solvent was evaporated off, and the residue was induced to crystallized with diethyl ether. Colorless crystals, melting point 145°-146° C.

Workup

  1. customThe solvent was evaporated off
  2. customto crystallized with diethyl ether

Sources & evidence

ORD record
ord-3a8a997edcbe41df892afb3d6cd33ffd
Source dataset
uspto-grants-1989_07
Patent number
US04845118

Reaction notes

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