Thionyl Chloride → HCID 14154317, compound

Participants

Reaction Steps

To a mixture of 2.6 g of 3-chloro-2-hydroxymethyl-4-methoxypyridine and 30 ml of dichloromethane at -10 to -15° C. was added dropwise a solution of 3.5 ml of thionyl chloride in 25 ml of dichloromethane, and then the mixture was stirred at room temperature for 2 hours. The solvent was evaporated off, and the residue was induced to crystallized with diethyl ether. Colorless crystals, melting point 145°-146° C.

Provenance & Evidence