Potassium Cation → N-(2-Methoxymethylimidazo[1,2-a]pyrid-7-yl)-5-fluoro-1-[(3-fluorophenyl)-methyl]-1H-indole-2-carboxamide

HRID 2311883Notes

Reaction equation

HRID 2311883 reaction equation
[Br:22][c:23]1[cH:24][c:25]2[n:26]([cH:27][cH:28]1)[cH:29][c:30]([CH2:32][O:33][CH3:34])[n:31]2.[C:35](=[O:36])([O-:37])[O-:38].[CH:41]1([NH2:42])[CH2:43][CH2:44][CH2:45][CH2:46][CH:47]1[NH2:48].[Cu:49]([I:50])[I:51].[F:1][c:2]1[cH:3][c:4]2[cH:5][c:6]([C:19](=[O:20])[NH2:21])[n:7]([CH2:11][c:12]3[cH:13][c:14]([F:18])[cH:15][cH:16][cH:17]3)[c:8]2[cH:9][cH:10]1.[K+:39].[K+:40].[O:53]1[CH2:54][CH2:55][O:56][CH2:57][CH2:58]1.[OH2:52]>>[F:1][c:2]1[cH:3][c:4]2[cH:5][c:6]([C:19](=[O:20])[NH:21][c:23]3[cH:24][c:25]4[n:26]([cH:27][cH:28]3)[cH:29][c:30]([CH2:32][O:33][CH3:34])[n:31]4)[n:7]([CH2:11][c:12]3[cH:13][c:14]([F:18])[cH:15][cH:16][cH:17]3)[c:8]2[cH:9][cH:10]1

Participants

9

Reactant 8

HCID 813Potassium Cation2×HCID 962WaterHCID 46101,2-DiaminocyclohexaneHCID 19660Carbonate IonHCID 312751,4-DioxaneHCID 83717Copper iodideHCID 581039787-Bromo-2-methoxymethylimidazo[1,2-a]pyridineHCID 668456965-Fluoro-1-(3-fluorobenzyl)-1H-indole-2-carboxamide

Product 1

HCID 66863766N-(2-Methoxymethylimidazo[1,2-a]pyrid-7-yl)-5-fluoro-1-[(3-fluorophenyl)-methyl]-1H-indole-2-carboxamide

Sources & evidence

ORD record
ord-28bc8eba9110404fb70bb97ce0e347c4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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