Acetone → Donepezil

HRID 2312302Notes

Reaction equation

HRID 2312302 reaction equation
[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:24]([cH:25][c:26]1[O:27][CH3:28])[C:22](=[O:23])[CH:7]([CH2:8][CH:9]1[CH2:10][CH2:11][N:12]([CH2:15][c:16]3[cH:17][cH:18][cH:19][cH:20][cH:21]3)[CH2:13][CH2:14]1)[CH2:6]2.[CH3:29][S:30]([OH:31])(=[O:32])=[O:33].[CH3:34][C:35](=[O:36])[CH3:37].[CH3:38][CH2:39][OH:40]>>[CH3:1][O:2][c:3]1[cH:4][c:5]2[c:24]([cH:25][c:26]1[O:27][CH3:28])[C:22](=[O:23])[CH:7]([CH2:8][CH:9]1[CH2:10][CH2:11][N:12]([CH2:15][c:16]3[cH:17][cH:18][cH:19][cH:20][cH:21]3)[CH2:13][CH2:14]1)[CH2:6]2.[CH3:29][S:30](=[O:31])(=[O:32])[OH:33]

Participants

6

Reactant 4

HCID 180AcetoneHCID 702EthanolHCID 3152DonepezilHCID 6395Methanesulfonic Acid

Product 2

HCID 3152DonepezilHCID 6395Methanesulfonic Acid

Sources & evidence

ORD record
ord-100c6c1dc4834701b7c03221fcd1e5f8
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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