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HRID231238

反应详情

EQUATION

反应方程式

HRID 231238 的结构方程式

REACTANTS

反应物

1
结构：C[C@@H](O)[C@@H]1C(=O)N([Si](C)(C)C(C)(C)C)[C@@H]1C#C[Si](C)(C)C
HCID67788869

未命名化合物

PRODUCTS

生成物

1
结构：CC(=O)[C@@H]1C(=O)N([Si](C)(C)C(C)(C)C)[C@H]1C#C[Si](C)(C)C
HCID53923800

未命名化合物

收率 93.9%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Mn+4].[O-2].[O-2]
催化剂HCID178418406

未命名化合物

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

CONDITIONS

反应条件

温度
25 °C

PROCEDURE

实验过程

Cis-1-(tert-butyldimethylsilyl)-3-[(R)-1-hydroxyethyl]-4-trimethylsilylethynyl-2-azetidinone (0.15 g) is dissolved in ethyl acetate (20 ml), and 5 g of activated manganese dioxide is added, followed by stirring at 25° C. for 5 hours. The manganese dioxide is filtered off and the filtrate is concentrated to give trans-3-acetyl-1-(tert-butyldimethylsilyl)-4-trimethylsilylethynyl-2-azetidinone (0.14 g).

WORKUP

后处理

  1. filtrationThe manganese dioxide is filtered off
  2. concentrationthe filtrate is concentrated