Triethylamine → HCID 14501040, compound

HRID 231258Notes

Reaction equation

HRID 231258 reaction equation
[CH3:1][O:2][CH:3]([CH2:15][O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[CH2:4][S:5]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][OH:14])(=[O:7])=[O:6].C(N(CC)CC)C.[CH3:42][S:43](Cl)(=[O:45])=[O:44]>ClCCl>[CH3:1][O:2][CH:3]([CH2:15][O:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH3:34])[CH2:4][S:5]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][O:14][S:43]([CH3:42])(=[O:45])=[O:44])(=[O:7])=[O:6]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 14501039HCID 14501039, compound

Product 1

HCID 14501040HCID 14501040, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In 30 ml of dichloromethane are dissolved 1.77 g of 6-hydroxyhexyl 2-methoxy-3-octadecyloxypropyl sulfone and 0.64 ml of triethylamine, to which 0.35 ml of methanesulfonyl chloride is added dropwise with stirring at room temperature. Thereafter, the mixture is stirred at room temperature for 2 hours and the solvent is distilled off under reduced pressure. The residue is dissolved in ethyl acetate and washed successively with dilute hydrochloric acid, water, an aqueous sodium bicarbonate solution and water. After drying, the solvent is distilled off to leave 1.98 g of the captioned compound.

Workup

  1. stirringThereafter, the mixture is stirred at room temperature for 2 hours
  2. distillationthe solvent is distilled off under reduced pressure
  3. dissolutionThe residue is dissolved in ethyl acetate
  4. washwashed successively with dilute hydrochloric acid, water
  5. customAfter drying
  6. distillationthe solvent is distilled off

Sources & evidence

ORD record
ord-c401de8f60d14445989cbae64dc3e275
Source dataset
uspto-grants-1989_07
Patent number
US04845219

Reaction notes

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