Methyl Methanesulfonate → 2-[(2-Methoxy-3-octadecyloxypropyl)sulfonyl]ethyltrimethylammonium mesylate

HRID 231263Notes

Reaction equation

[CH3:1][O:2][CH:3]([CH2:13][O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[CH2:4][S:5]([CH2:8][CH2:9][N:10]([CH3:12])[CH3:11])(=[O:7])=[O:6].[CH3:33][S:34]([O:37]C)(=[O:36])=[O:35]>C(Cl)(Cl)Cl>[S:34]([O-:37])(=[O:36])(=[O:35])[CH3:33].[CH3:1][O:2][CH:3]([CH2:13][O:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32])[CH2:4][S:5]([CH2:8][CH2:9][N+:10]([CH3:33])([CH3:12])[CH3:11])(=[O:6])=[O:7]

Participants

Conditions

Temperature: 70 °C

Procedure

In 10 ml of chloroform are dissolved 0.48 g of 2-[(2-methoxy-3-octadecyloxypropyl)sulfonyl]ethyldimethylamine and 1 g of methyl methanesulfonate and the solution is stirred at 70° C. for 5 hours. Then the reaction mixture is concentrated under reduced pressure and the residue is crystallized from chloroform and ether to give 417 mg of the captioned compound.

Workup

concentrationThen the reaction mixture is concentrated under reduced pressure
customthe residue is crystallized from chloroform and ether

Sources & evidence

ORD record: ord-1c6f273932834c8c827785532613c3dc
Source dataset: uspto-grants-1989_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04845219

Reaction notes

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