Dichloromethane → HCID 14877725, compound

HRID 231270Notes

Reaction equation

HRID 231270 reaction equation
ClCCl.[CH:4]1([CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][O:22][CH2:23][CH:24]([CH2:27][OH:28])[O:25][CH3:26])[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1.[CH3:29][S:30](Cl)(=[O:32])=[O:31]>C(N(CC)CC)C>[CH3:29][S:30]([O:28][CH2:27][CH:24]([O:25][CH3:26])[CH2:23][O:22][CH2:21][CH2:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1)(=[O:32])=[O:31]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 31297Methanesulfonyl chlorideHCID 147189253-[(12-Cyclohexyldodecyl)oxy]-2-methoxypropan-1-ol

Product 1

HCID 14877725HCID 14877725, compoundYield 79.1%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

To 100 ml of dichloromethane are added 10.8 g of 1-(12-cyclohexyldodecyl)-2-methylglycerine and 4.42 ml of triethylamine, to which 3.64 g of methanesulfonyl chloride is added dropwise with stirring under ice cooling. Then, the mixture is stirred at room temperature for 2 hours to complete the reaction. The reaction mixture is washed with water, an aqueous sodium bicarbonate solution and water, and dried. The solvent is removed by distillation to leave 10.42 g of the captioned compound.

Workup

  1. stirringThen, the mixture is stirred at room temperature for 2 hours
  2. customthe reaction
  3. washThe reaction mixture is washed with water
  4. dry with materialan aqueous sodium bicarbonate solution and water, and dried
  5. customThe solvent is removed by distillation

Sources & evidence

ORD record
ord-30221152183f4c70a1552256eada1a9e
Source dataset
uspto-grants-1989_07
Patent number
US04845219

Reaction notes

Loading…