6-Chloro-2-methylnicotinonitrile → 2-[(5-Cyano-6-methylpyridin-2-yl)amino]-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

HRID 2312969Notes

Reaction equation

HRID 2312969 reaction equation
[Cl:22][c:23]1[n:24][c:25]([CH3:31])[c:26]([C:27]#[N:28])[cH:29][cH:30]1.[NH2:1][c:2]1[s:3][c:4](-[c:10]2[c:11]([F:21])[cH:12][c:13]([C:17]([CH3:18])([CH3:19])[OH:20])[cH:14][c:15]2[F:16])[cH:5][c:6]1[C:7](=[O:8])[NH2:9]>>[NH:1]([c:2]1[s:3][c:4](-[c:10]2[c:11]([F:21])[cH:12][c:13]([C:17]([CH3:18])([CH3:19])[OH:20])[cH:14][c:15]2[F:16])[cH:5][c:6]1[C:7](=[O:8])[NH2:9])[c:23]1[n:24][c:25]([CH3:31])[c:26]([C:27]#[N:28])[cH:29][cH:30]1

Participants

3

Reactant 2

HCID 123877376-Chloro-2-methylnicotinonitrileHCID 595256192-Amino-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Product 1

HCID 595256772-[(5-Cyano-6-methylpyridin-2-yl)amino]-5-[2,6-difluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide

Sources & evidence

ORD record
ord-6baacde0bd68440c91b5fd070a4735cb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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