Bicarbonate Ion → 3-Amino-6-chloro-2-[2-chloro-5-(2,3-difluoro-6-methoxybenzyloxy)-4-methoxy-phenylamino]pyridine
Reaction equation
[BH4-:33].[C:35](=[O:36])([O-:37])[OH:38].[Cl:1][c:2]1[cH:3][cH:4][c:5]([N+:30]([O-:31])=[O:32])[c:6]([NH:8][c:9]2[c:10]([Cl:29])[cH:11][c:12]([O:27][CH3:28])[c:13]([O:15][CH2:16][c:17]3[c:18]([F:26])[c:19]([F:25])[cH:20][cH:21][c:22]3[O:23][CH3:24])[cH:14]2)[n:7]1.[Na+:34].[Na+:39].[Ni:45]([Br:46])[Br:47].[O:40]1[CH2:41][CH2:42][CH2:43][CH2:44]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]([NH2:30])[c:6]([NH:8][c:9]2[c:10]([Cl:29])[cH:11][c:12]([O:27][CH3:28])[c:13]([O:15][CH2:16][c:17]3[c:18]([F:26])[c:19]([F:25])[cH:20][cH:21][c:22]3[O:23][CH3:24])[cH:14]2)[n:7]1Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-c8b5c0cd024a4fe1b6d231b1de345528
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (10/10)
Reaction notes
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