Bromine → 1-Bromo-3,3-dimethyl-1-(1H-1,2,4-triazol-1-yl)butan-2-one
Reaction equation
C1(C)CCC(C(C)C)[CH:3]([C:10]([CH:20]2C(C(C)C)CCC(C)C2)([CH3:19])[C:11](=[O:18])[CH2:12][N:13]2[CH:17]=[N:16][CH:15]=[N:14]2)C1.[Br:31]Br>>[Br:31][CH:12]([N:13]1[CH:17]=[N:16][CH:15]=[N:14]1)[C:11](=[O:18])[C:10]([CH3:20])([CH3:19])[CH3:3]Participants
3
Procedure
Thus, for example, 3,3-dimethyl-1-(4-methoximinomethyl-phenoxy)-1-(1,2,4-triazol-1-yl)-butan-2-one of the formula ##STR11## can be prepared by reacting 3,3-dimenthyl-1-(1,2,4-triazol-1-yl)-butan-2-one initially with bromine to form 1-bromo-(1,2,4-triazol-1-yl)-3,3-dimethyl-butan-2-one, and subsequently reaching this with 4-hydroxybenzaldehyde O-methyl oxime ether in the presence of a base. This synthesis can be illustrated by means of formulae as follows:
Sources & evidence
- ORD record
- ord-e4f9a736b7cf40b8bde40e1b8150d5db
- Source dataset
- uspto-grants-1989_07
- Patent number
- US04845288
Reaction notes
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