Tetrahydrofuran → 2-amino-5-(4-hydroxycyclohexyl)-N,N-dimethylbenzamide

HRID 2313674Notes

Reaction equation

[CH2:28]([N+:29]([CH2:30][CH2:31][CH2:32][CH3:33])([CH2:34][CH2:35][CH2:36][CH3:37])[CH2:38][CH2:39][CH2:40][CH3:41])[CH2:42][CH2:43][CH3:44].[CH2:45]1[O:46][CH2:47][CH2:48][CH2:49]1.[F-:27].[NH2:1][c:2]1[c:3]([C:4](=[O:5])[N:6]([CH3:7])[CH3:8])[cH:9][c:10]([CH:13]2[CH2:14][CH2:15][CH:16]([O:19][Si:20]([C:21]([CH3:22])([CH3:23])[CH3:24])([CH3:25])[CH3:26])[CH2:17][CH2:18]2)[cH:11][cH:12]1>>[NH2:1][c:2]1[c:3]([C:4](=[O:5])[N:6]([CH3:7])[CH3:8])[cH:9][c:10]([CH:13]2[CH2:14][CH2:15][CH:16]([OH:19])[CH2:17][CH2:18]2)[cH:11][cH:12]1

Participants

Reactant 4

HCID 8028Tetrahydrofuran

HCID 16028Tetrabutylammonium

HCID 28179Fluoride Ion

HCID 672546822-amino-5-(4-{[tert-butyl(dimethyl)silyl]oxy}cyclohexyl)-N,N-dimethylbenzamide

Product 1

HCID 672547852-amino-5-(4-hydroxycyclohexyl)-N,N-dimethylbenzamide

Sources & evidence

ORD record: ord-f223b6f6928e4665b1513a6dc2bd86c9
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (10/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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