反应详情

By procedures described in Example 1, α-ethylphenethyl chloride and acetonitrile were converted to 1-methyl-3-ethyl-1,2,3,4-tetrahydroisoquinoline. A reaction vessel was charged with 3 g of this isoquinoline compound, 10 ml 10% sodium hydroxide and 50 ml methylene chloride. With this mixture stirred, 1.1 equivalents dichloroacetyl chloride was added dropwise to the mixture. The mixture was stirred for 15 minutes, then water was added. The organic extract was dried with magnesium sulfate, stripped of solvent and chromatographed. A yellow oil product was recovered having the following elemental analysis:

1. stirringThe mixture was stirred for 15 minutes
2. extractionThe organic extract
3. dry with materialwas dried with magnesium sulfate
4. customchromatographed
5. customA yellow oil product was recovered