Borane → 4-Hydroxymethyl-pyrrolidine-1,2-dicarboxylic acid di-tert-butyl ester

HRID 2314094Notes

Reaction equation

HRID 2314094 reaction equation
[BH3:28].[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:10][CH:11]([C:13](=[O:14])[OH:15])[CH2:12]1.[O:23]1[CH2:24][CH2:25][CH2:26][CH2:27]1.[O:29]1[CH2:30][CH2:31][CH2:32][CH2:33]1>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH:9]([C:16](=[O:17])[O:18][C:19]([CH3:20])([CH3:21])[CH3:22])[CH2:10][CH:11]([CH2:13][OH:14])[CH2:12]1

Participants

4

Reactant 3

HCID 6331BoraneHCID 8028Tetrahydrofuran2×HCID 68544941Pyrrolidine-1,2,4-tricarboxylic acid 1,2-di-tert-butyl ester

Product 1

HCID 189679154-Hydroxymethyl-pyrrolidine-1,2-dicarboxylic acid di-tert-butyl ester

Sources & evidence

ORD record
ord-4ea4c7d95efa4728ada42c2b9207838f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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