Dichloromethane → 1-(4-(2-Aminopyrimidin-4-yloxy)naphthalen-1-yl)-3-(3-tert-butyl-1-p-tolyl-1 H-pyrazol-5-yl)urea

HRID 2314175Notes

Reaction equation

HRID 2314175 reaction equation
[C:13]([CH3:14])([CH3:15])([CH3:16])[c:17]1[n:18][n:19](-[c:23]2[cH:24][cH:25][c:26]([CH3:29])[cH:27][cH:28]2)[c:20]([NH2:22])[cH:21]1.[C:1](=[O:2])([n:3]1[cH:4][cH:5][n:6][cH:7]1)[n:8]1[cH:9][cH:10][n:11][cH:12]1.[Cl:49][CH2:50][Cl:51].[NH2:30][c:31]1[cH:32][cH:33][c:34]([O:41][c:42]2[n:43][c:44]([NH2:48])[n:45][cH:46][cH:47]2)[c:35]2[cH:36][cH:37][cH:38][cH:39][c:40]12>>[C:1](=[O:2])([NH:22][c:20]1[n:19](-[c:23]2[cH:24][cH:25][c:26]([CH3:29])[cH:27][cH:28]2)[n:18][c:17]([C:13]([CH3:14])([CH3:15])[CH3:16])[cH:21]1)[NH:30][c:31]1[cH:32][cH:33][c:34]([O:41][c:42]2[n:43][c:44]([NH2:48])[n:45][cH:46][cH:47]2)[c:35]2[cH:36][cH:37][cH:38][cH:39][c:40]12

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 682631,1'-CarbonyldiimidazoleHCID 29741323-tert-butyl-1-(4-methylphenyl)-1H-pyrazol-5-amineHCID 207688484-(4-Aminonaphthalen-1-yloxy)pyrimidin-2-amine

Product 1

HCID 585647671-(4-(2-Aminopyrimidin-4-yloxy)naphthalen-1-yl)-3-(3-tert-butyl-1-p-tolyl-1 H-pyrazol-5-yl)urea

Sources & evidence

ORD record
ord-e320c16e753b46ea851ced2835b04803
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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