Formic Acid → 2-Chloro-4-fluorobenzaldehyde

In a flask were placed 30.25 g (0.100 mole) of 2-chloro-4-fluorobenzal bromide, 45 ml (1.2 mole) of formic acid, and 15 ml of concentrated hydrochloric acid. This mixture was heated at 100°-105° C. overnight. After cooling to room temperature, the reaction mixture was poured into 200 ml of an ice/water mixture which was then extracted twice with diethyl ether. The combined extracts were washed successively with a saturated, aqueous, sodium bicarbonate solution and water. After being dried over anhydrous magnesium sulfate, the extract was filtered, and the solvent was evaporated under reduced pressure, leaving 17 g of 2-chloro-4-fluorobenzaldehyde as a residue.

1. customIn a flask were placed
2. temperatureThis mixture was heated at 100°-105° C. overnight
3. extractionwas then extracted twice with diethyl ether
4. washThe combined extracts were washed successively with a saturated, aqueous, sodium bicarbonate solution and water
5. dry with materialAfter being dried over anhydrous magnesium sulfate
6. filtrationthe extract was filtered
7. customthe solvent was evaporated under reduced pressure

ORD record

ord-c96fdab71ea54d868976dcd54163cebf

Source dataset

uspto-grants-1989_07

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US04846882