HCID 20032349, compound → HCID 20032372, compound

HRID 231452Notes

Reaction equation

HRID 231452 reaction equation
[Cl:1][C:2]1[CH:14]=[C:13]([F:15])[C:12]([N+:16]([O-])=O)=[CH:11][C:3]=1[CH2:4][N:5]([O:9][CH3:10])[C:6](=[O:8])[CH3:7]>C(O)(=O)C.[Pt]=O>[C:6]([N:5]([CH2:4][C:3]1[C:2]([Cl:1])=[CH:14][C:13]([F:15])=[C:12]([CH:11]=1)[NH2:16])[O:9][CH3:10])(=[O:8])[CH3:7]

Participants

4

Reactant 1

HCID 20032349HCID 20032349, compound

Product 1

HCID 20032372HCID 20032372, compoundYield 99.3%

Reagents, catalysts & solvents 2

HCID 82844Platinum oxide (PtO)CatalystHCID 176Acetic AcidSolvent

Procedure

N-(2-chloro-4-fluoro-5-nitrobenzyl)-N-methoxyacetamide (1.1 g, 0.0040 mole) was hydrogenated with a small amount (0.1 g) of platinum oxide in 50 ml of acetic acid. The reaction mixture was filtered to leave a solution of 5-[(N-acetyl-N-methoxyamino)methyl]-4-chloro-2-fluoroaniline (0.98 g) dissolved in 50 ml of acetic acid.

Workup

  1. filtrationThe reaction mixture was filtered

Sources & evidence

ORD record
ord-1d96a485caf1452eba510e8197043fd9
Source dataset
uspto-grants-1989_07
Patent number
US04846882

Reaction notes

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