Hydrochloric Acid → HCID 23039021, compound

HRID 231484Notes

Reaction equation

HRID 231484 reaction equation
[CH2:1]([N:4]([CH2:18][CH2:19][CH3:20])[CH2:5][C:6]1(O)[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH3:16])[CH:13]=2)[CH2:8][CH2:7]1)[CH2:2][CH3:3].Cl.[H][H]>CO.[Pd].O>[CH2:18]([N:4]([CH2:1][CH2:2][CH3:3])[CH2:5][CH:6]1[C:14]2[C:9](=[CH:10][CH:11]=[C:12]([O:15][CH3:16])[CH:13]=2)[CH2:8][CH2:7]1)[CH2:19][CH3:20]

Participants

7

Reactant 3

HCID 313Hydrochloric AcidHCID 23039063HCID 23039063, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 23039021HCID 23039021, compound

Reagents, catalysts & solvents 3

HCID 962WaterCatalystHCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

12 g of N,N-dipropyl-1-hydroxy-6-methoxy-1-indanmethylamine were dissolved in 100 milliliters of methanol and 7 milliliters of concentrated hydrochloric acid and reduced catalytically with hydrogen at 3 atmospheres and 50 degrees Centigrade for 20 hours with 10 g of 5% palladium on carbon black containing 50% of water as a catalyst. After filtration of the catalyst and evaporation of the methanol 13 grams of product were obtained. The oxalate was precipitated from acetone. M.P. 124°-130° C.

Workup

  1. filtrationAfter filtration of the catalyst and evaporation of the methanol 13 grams of product
  2. customwere obtained
  3. customThe oxalate was precipitated from acetone

Sources & evidence

ORD record
ord-c55bcfb06fbf43e2b1dbc695526eb468
Source dataset
uspto-grants-1989_07
Patent number
US04847254

Reaction notes

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