HCID 73553870, compound → HCID 58051386, compound

HRID 231487Notes

Reaction equation

HRID 231487 reaction equation
[CH3:1][O:2][C:3](=[O:16])[CH2:4][C:5]1[O:9][C:8]2[CH:10]=[CH:11][C:12]([O:14][CH3:15])=[CH:13][C:7]=2[CH:6]=1>C(O)C.[Pd]>[CH3:1][O:2][C:3](=[O:16])[CH2:4][CH:5]1[O:9][C:8]2[CH:10]=[CH:11][C:12]([O:14][CH3:15])=[CH:13][C:7]=2[CH2:6]1

Participants

4

Reactant 1

HCID 73553870HCID 73553870, compound

Product 1

HCID 58051386HCID 58051386, compoundYield 83.2%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

50 g of 5-methoxy-3-benzofuranacetic acid methylester were dissolved in 200 ml of ethanol, and 18 g of 5% Pd on carbon black (50% water) were added. Hydrogenation was performed at 3 ato. for 4 hours at 65° C. The catalyst was filtered off, and ethanol evaporated yielding 42 g of an oil, which was not further purified before use in the next step.

Workup

  1. filtrationThe catalyst was filtered off
  2. customethanol evaporated

Sources & evidence

ORD record
ord-a1916e5f355f43c39f192d5231e4808f
Source dataset
uspto-grants-1989_07
Patent number
US04847254

Reaction notes

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