反应详情

30 g of 5-amino-N,N-dipropyl-3-benzothiophencarboxamide were dissolved in 250 ml of dry methanol. 15 g of magnesium turnings were added (eventually activated by addition of a few drops of 1,2-dibromoethane). The mixture was stirred at 30°-35° C. for 4 hours with periodically cooling to keep the temperature down. 2 l of a saturated ammonium chloride solution were added and the product extracted with ethyl acetate. The organic phase was separated, washed with water, dried (MgSO4) and the solvent evaporated. Isopropyl ether was added, and by cooling the title compound precipitated and was filtered off. Yield: 20 g. M.P. 100° C.

1. temperaturewith periodically cooling
2. extractionthe product extracted with ethyl acetate
3. customThe organic phase was separated
4. washwashed with water
5. dry with materialdried (MgSO4)
6. customthe solvent evaporated
7. additionIsopropyl ether was added
8. temperatureby cooling the title compound
9. customprecipitated
10. filtrationwas filtered off