反应详情

A mixture of 75.0 g of m-chloropropiophenone and 200 ml of N,N-dimethylformamide dimethyl acetal was stirred and heated at reflux for 16 hours. The mixture was evaporated in vacuo to give a black oil. The oil was subjected to Kugelrohr distillation at 0.5 mm of mercury and the fraction that boils at 110° C. was removed. The residue from the distillation was collected to give 35.0 g of 3'-chloro-3-dimethylamino-2-methylacrylophenone as a black oil.

1. temperatureheated
2. temperatureat reflux for 16 hours
3. customThe mixture was evaporated in vacuo
4. customto give a black oil
5. distillationThe oil was subjected to Kugelrohr distillation at 0.5 mm of mercury
6. customthe fraction that boils at 110° C. was removed
7. distillationThe residue from the distillation
8. customwas collected