Dichloromethane → Trifluoroacetic acid

HRID 2315282Notes

Reaction equation

HRID 2315282 reaction equation
[C:1](#[N:2])[CH2:3][CH:4]([n:5]1[n:6][cH:7][c:8](-[c:10]2[c:11]3[c:12]([n:13][cH:14][n:15]2)[n:16]([CH2:19][O:20][CH2:21][CH2:22][Si:23]([CH3:24])([CH3:25])[CH3:26])[cH:17][cH:18]3)[cH:9]1)[C:27]1([C:30]#[N:31])[CH2:28][CH2:29]1.[Cl:39][CH2:40][Cl:41].[F:32][C:33]([C:34](=[O:35])[OH:36])([F:37])[F:38]>>[C:1](#[N:2])[CH2:3][CH:4]([n:5]1[n:6][cH:7][c:8](-[c:10]2[c:11]3[c:12]([n:13][cH:14][n:15]2)[nH:16][cH:17][cH:18]3)[cH:9]1)[C:27]1([C:30]#[N:31])[CH2:28][CH2:29]1.[F:32][C:33]([C:34](=[O:35])[OH:36])([F:37])[F:38]

Participants

5

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 66597812HCID 66597812, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 578813981-[2-cyano-1-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]ethyl]cyclopropane-1-carbonitrile

Sources & evidence

ORD record
ord-508305f92d5a485baca1239d4cd63f22
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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