Ethanone, 1-(2,5-dichlorophenyl)- → 1-(2,5-Dichlorophenyl)-3-(dimethylamino)-2-buten-1-one

Participants

Reaction Steps

A mixture of 50.0 g of 2,5-dichloroacetophenone and 50 ml of N,N-dimethylacetamide dimethyl acetal was stirred and heated at reflux for 121/2 hours. The mixture was then cooled and evaporated in vacuo to give an oil which crystallized on scratching to give a dark red solid. This was collected and washed with hexane/ether to give 58.8 g of 1-(2,5-dichlorophenyl)-3-(dimethylamino)-2-buten-1-one as a red solid.

Provenance & Evidence