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A mixture of 50.0 g of 2,5-dichloroacetophenone and 50 ml of N,N-dimethylacetamide dimethyl acetal was stirred and heated at reflux for 121/2 hours. The mixture was then cooled and evaporated in vacuo to give an oil which crystallized on scratching to give a dark red solid. This was collected and washed with hexane/ether to give 58.8 g of 1-(2,5-dichlorophenyl)-3-(dimethylamino)-2-buten-1-one as a red solid.

1. temperatureheated
2. temperatureat reflux for 121/2 hours
3. temperatureThe mixture was then cooled
4. customevaporated in vacuo
5. customto give an oil which
6. customcrystallized
7. customto give a dark red solid
8. customThis was collected
9. washwashed with hexane/ether