反应详情

A mixture of 50.0 g of 3,4-dichloroacetophenone and 75 ml of N,N-dimethylformamide dimethyl acetal was heated under reflux for 6 hours, then allowed to cool for 16 hours. The crystalline precipitate was collected by filtration, washed with hexane and dried. The addition of hexane to the above filtrate precipitated some additional product which was collected by filtration. The precipitates were combined, washed with hexane and dried in vacuo to give 55.0 g of 3',4'-dichloro-3-dimethylaminoacrylophenone as bright yellow crystals.

1. temperaturewas heated
2. temperatureunder reflux for 6 hours
3. temperatureto cool for 16 hours
4. filtrationThe crystalline precipitate was collected by filtration
5. washwashed with hexane
6. customdried
7. additionThe addition of hexane to the above filtrate
8. customprecipitated some additional product which
9. filtrationwas collected by filtration
10. washwashed with hexane
11. customdried in vacuo