反应详情

20 g (77.8 mmol) of 2-amino-5-chloropyridine dissolved in 160 ml of CH2Cl2 are reacted with 8 ml of bromine, which is added dropwise at 0° C. After the addition is complete, the mixture is left to react at 25° C. for 2 h. The suspension is washed with 10% strength sodium hydroxide solution, and the organic phase is washed with water and then dried over MgSO4, filtered and evaporated. The compound obtained is recrystallized in isopropanol. M.p. 82° C.

1. additionis added dropwise at 0° C
2. additionAfter the addition
3. waitthe mixture is left
4. customto react at 25° C. for 2 h
5. washThe suspension is washed with 10% strength sodium hydroxide solution
6. washthe organic phase is washed with water
7. dry with materialdried over MgSO4
8. filtrationfiltered
9. customevaporated
10. customThe compound obtained
11. customis recrystallized in isopropanol