Piperidin-4-ol → 2-Chloro-6-(4-hydroxypiperidin-1-yl)isonicotinamide

HRID 2316203Notes

Reaction equation

HRID 2316203 reaction equation
[Cl:17][c:18]1[cH:19][c:20]([C:26](=[O:22])[NH2:27])[cH:21][c:23]([Cl:24])[n:25]1.[Cl:1][c:2]1[cH:3][c:4]([C:5]#[N:6])[cH:7][c:8]([N:10]2[CH2:11][CH2:12][CH:13]([OH:16])[CH2:14][CH2:15]2)[n:9]1.[OH:28][CH:29]1[CH2:30][CH2:31][NH:32][CH2:33][CH2:34]1>>[Cl:1][c:2]1[cH:3][c:4]([C:5]([NH2:6])=[O:22])[cH:7][c:8]([N:10]2[CH2:11][CH2:12][CH:13]([OH:16])[CH2:14][CH2:15]2)[n:9]1

Participants

4

Reactant 3

HCID 79341Piperidin-4-olHCID 27818022,6-DichloroisonicotinamideHCID 830734032-Chloro-6-(4-hydroxypiperidin-1-yl)isonicotinonitrile

Product 1

HCID 860383812-Chloro-6-(4-hydroxypiperidin-1-yl)isonicotinamide

Sources & evidence

ORD record
ord-8a9e8b79a67d4933a05c73ffb8ddbcaa
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (10/10)

Reaction notes

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