反应详情

温度

10 °C

Thionyl chloride (50 ml) was stirred under nitrogen in an ice bath while 4-hydroxymethyl-5-methylimidazole (11.2 g, 0.1 m) was added in very small portions over a 15 minute period. The reaction was vigorous and the temperature was maintained between 10° and 20° C. A colorless precipitate formed. When the addition was complete, the temperature was raised slowly (about 1/2 hour) to 55°±5° C. and maintained at that level for about 1/2 hour. The mixture was then cooled to 10° C. and diluted with 100 ml of diethyl ether. The colorless precipitate was collected by filtration, washed well with diethyl ether and dried in air to give 15.23 g (91% yield) of 4-methyl-5-chloromethyl imidazole hydrochloride, m.p. 208°-211° C. (dec.).

1. additionwas added in very small portions over a 15 minute period
2. temperaturethe temperature was maintained between 10° and 20° C
3. customA colorless precipitate formed
4. additionWhen the addition
5. temperaturethe temperature was raised slowly (about 1/2 hour) to 55°±5° C.
6. temperaturemaintained at that level for about 1/2 hour
7. filtrationThe colorless precipitate was collected by filtration
8. washwashed well with diethyl ether
9. customdried in air